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Old 15-08-2022, 15:40   #2161
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Re: Coronavirus

Quote:
Originally Posted by mrmistoffelees View Post

Indeed it is. For me the value of popping doses of the original vaccine in when we have omicron was always going to be limited efficacy and even more so when we keep doing it.


If they are going to use this as the booster this winter, then we have every chance of being in more control of any omicron variants, provided they don't mutate past the protection of the newer vaccines further.


Realistically think they should also make this roll out open to everyone, as well, once they have protected the older people and those with the at-risk conditions, of course. If we get another covid spike the amount of under 50s who are ill with it and not able to work might cause issues in its own right.
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Old 15-08-2022, 15:44   #2162
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Re: Coronavirus

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Originally Posted by Pierre View Post
Great a dual vaccine. Hope it's better than the others that:

Don't stop you catching it.
Don't stop you spreading it.
Don't stop you getting ill from it.
They do lessen the chances of you getting seriously ill
They do lessen the chances of those that get seriously ill subsequently dying

Is that not enough ?
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Old 15-08-2022, 16:32   #2163
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Re: Coronavirus

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Originally Posted by mrmistoffelees View Post
They do lessen the chances of you getting seriously ill
They do lessen the chances of those that get seriously ill subsequently dying

Is that not enough ?
Not really no.

I'm also looking forward to seeing the studies, if any are produced, that show the effectiveness of the above in fit and healthy <50 year olds, and subsequent age ranges.

I think it's clear the vaccines for the elderly and infirm helped, what's less clear is their effectiveness for younger fit and healthy people.
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Old 15-08-2022, 16:44   #2164
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Re: Coronavirus

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Originally Posted by Pierre View Post
Not really no.

I'm also looking forward to seeing the studies, if any are produced, that show the effectiveness of the above in fit and healthy <50 year olds, and subsequent age ranges.

I think it's clear the vaccines for the elderly and infirm helped, what's less clear is their effectiveness for younger fit and healthy people.
I think the studies showed in general that with two doses of original AZ, Moderna or Pfizer vaccine, against the original strains and similar variants such as Alpha, which were widely circulating at the time of the initial roll out and lockdown easing, the effectiveness against symptomatic infection (not just hospitalisation and death) was very high, certainly in the 90s with the mRNA vaccine.


When we got the Delta variant which was more contagious than Alpha but also had some immune escape from it, the efficacy dropped, but a third dose of the mRNA vaccine restored the efficacy to that of 2 shots against earlier variants.



By rolling out vaccine to all those people and triple dosing the vulnerable they were able to keep serious illness down though there was still significant spill over of Delta into double-vaccinated people who hadn't received a booster or third dose.


The mutations in original omicron (and the lineage variants aren't too dissimilar to be considered separate) meant that the spike protein protection most people had was much less recognisable to the immune system which is why we are now seeing plenty of vaccinated people get ill, but even then, the response from the vaccines is keeping plenty more out of hospital. Hopefully a more targeted vaccine will indeed erode at the infections and not just at the serious illness aspect and that this will be rolled out to all ages. Though I disagree that people should basically be coerced into vaccination and if they don't want it that choice should be respected.
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Old 15-08-2022, 16:47   #2165
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Re: Coronavirus

I wish they offered it in chemists to buy if you're willing like they do with the flu vaccine.

I am fine if I get COVID (again) but it was very annoying. A few days lost with fatigue and then another few days of feeling a bit sluggish. I would happliy pay £15/20 whatever it is to avoid that.
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Old 15-08-2022, 21:00   #2166
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Re: Coronavirus

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Originally Posted by mrmistoffelees View Post
First again! Good old Boris!

Sorry to see him go yet?
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Old 15-08-2022, 21:40   #2167
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Re: Coronavirus

Quote:
Originally Posted by OLD BOY View Post
First again! Good old Boris!

Sorry to see him go yet?
How was he involved? Did he call in from Slovenia or Greece to approve the US developed vaccine?

Actually, no, because it was approved by the UK's Medicines and Healthcare Products Regulatory Agency, not Johnson…
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Old 15-08-2022, 22:27   #2168
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Re: Coronavirus

Quote:
Originally Posted by OLD BOY View Post
First again! Good old Boris!

Sorry to see him go yet?
I mean, OB, even I can’t get on that bandwagon.
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Old 15-08-2022, 22:36   #2169
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Re: Coronavirus

Quote:
Originally Posted by Pierre View Post
I mean, OB, even I can’t get on that bandwagon.
Beware, Old Boy may be tempted to repeat his previous line "You are getting as cynical and downbeat as the socialist-minded posters on here! Please don’t encourage them, it is extremely depressing to hear all this negative nonsense."
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Old 16-08-2022, 00:40   #2170
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Re: Coronavirus

Quote:
Originally Posted by OLD BOY View Post
First again! Good old Boris!

Sorry to see him go yet?
Um .... not really.
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Old 16-08-2022, 11:19   #2171
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Re: Coronavirus

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Originally Posted by OLD BOY View Post
First again! Good old Boris!
I think there may be a job for you in North Korea's Ministry of Communications
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Old 16-08-2022, 12:18   #2172
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Re: Coronavirus

Quote:
Originally Posted by spiderplant View Post
I think there may be a job for you in North Korea's Ministry of Communications
Even they have a degree of standards as to what gibberish they’ll publish and think people will believe….
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Old 16-08-2022, 20:32   #2173
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Re: Coronavirus

Quote:
Originally Posted by Pierre View Post
Not really no.

I'm also looking forward to seeing the studies, if any are produced, that show the effectiveness of the above in fit and healthy <50 year olds, and subsequent age ranges.

I think it's clear the vaccines for the elderly and infirm helped, what's less clear is their effectiveness for younger fit and healthy people.
https://www.frontiersin.org/articles...21.758294/full

Quote:
Conclusion

The immune effect on young people after being vaccinated with COVID-19 vaccines was better than that of the elderly, but the safety was worse than that of old people; the most common AEs were fever, rash and local muscle pain, which were tolerable for young people. As the AEs of the elderly were lower, they can also be vaccinated safely, the reason for the low level of GMT in the elderly was related to Immunosenescence. The vaccine tolerance of people of different ages needs to be studied continuously.
https://observer.com/2021/04/covid19...a-jj-biontech/

Quote:
Below we’ve rounded up the latest efficacy rates of the three authorized vaccines in the U.S.—Pfizer, BioNTech and Johnson & Johnson—based on both trial and real-world data.

Pfizer-BioNTech: Overall 94% Effective
By Age Group:
100% for people ages 12 to 15;
95% for people age 16 and older;
94% for people age 65 and older;
61% for people 70 and older;
70% for people 80 and older.

Moderna: Overall 94.5% Effective
By Age Group:
95.6% for people ages 18 to 65;
86.4% for people older than 65.

Johnson & Johnson: Overall 66% Effective (74.4% in the U.S.)
By Age Group:
66.1% for people ages 18 to 59;
66.2% for people older and 60.
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Old 16-08-2022, 21:05   #2174
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Re: Coronavirus

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Originally Posted by spiderplant View Post
I think there may be a job for you in North Korea's Ministry of Communications
Not for me. They get blown up if they tell the truth.
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Old 16-08-2022, 21:34   #2175
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Re: Coronavirus

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Originally Posted by OLD BOY View Post
Not for me. They get blown up if they tell the truth.
You’d be safe…
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